The adsorption of immunoglobulin on alginate-based microcapsules
نویسندگان
چکیده
Important advances in the transplantation of islets of Langerhans have recently been achieved using alginate-based microcapsules (De Vos 2006). These microcapsules safely protect the transplanted cells from graft rejection in the absence of long-term immunosuppression. Recent progress has allowed us to effectively eliminate the development of fibrosis surrounding the implanted microcapsules (De Vos 2003). Nevertheless, the long-term viability of encapsulated islets in vivo is still limited.
منابع مشابه
Adsorption of human immunoglobulin to implantable alginate-poly-L-lysine microcapsules: effect of microcapsule composition.
Alginate-poly-L-lysine-alginate (APA) microcapsules continue to be the most widely studied device for the immuno-protection of transplanted therapeutic cells. Producing APA microcapsules having a reproducible and high level of biocompatibility requires an understanding of the mechanisms of the immune response towards the implants. Here, we investigate the adsorption of immunoglobulins (IgG, IgM...
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